This process is experimental and the keywords may be updated as the learning algorithm improves. These keywords were added by machine and not by the authors. Thus, a quantitative measure of cerebrovascular reactivity is important to help determine the underlying mechanisms leading to metabolic crisis and pressure/volume instability following severe head injury. However, with traumatic injury, vascular reactivity may be reduced thus compromising the volume compensatory response for ICP reduction as well as altering dynamics of cerebral blood flow. With regard to ICP control, it is the concomitant reduction in blood volume achieved in response to hyperventilation which remains a potent therapeutic tool in the patient with raised intracranial pressure. A two-way repeated measures ANOVA compared the cerebral hemodynamic and gas exchange variables during stepped hypercapnia followed by the Holm-Sidak method to test pairwise comparisons. By definition, cerebrovascular reactivity is defined as the change in blood flow (CBF) per torr change in PCO 2. Cerebrovascular reactivity and MAP reactivity slopes were compared between young and older adults using a one-way ANOVA. All other Topic Editors declare no competing interests with regards to the Research Topic subject.The ability to control ICP following traumatic head injury depends in part on cerebrovascular reactivity (CVR). RespirAct TM is currently a non-commercial research tool assembled and made available by TMI to research institutions to enable CVR studies. James Duffin contributed to the development of an automated end-tidal targeting device, RespirAct TM and is employed by Thornhill Medical Inc. Addressing the challenges of repeatability, reliability, and specificity of CVR metrics, including within problematic cohorts, during extreme CO 2 stimuli, across research sites, or spanning imaging modalities.Using MRI-based CVR to assess vascular health in various pathologies.Characterizing or modelling the physiology involved in the vascular response to CO 2 and how this reflects vascular health.Improving the analysis of MRI data to provide more information about CVR.Methods of measuring CVR with MRI and a CO 2 stimulus.The use of CVR to assess vascular health in various pathologies (e.g. Cerebral vasomotor reactivity (CVR) is reduced in patients with diabetes mellitus (DM), and glucose variability (GV) might be responsible for cerebrovascular.Relationships between CVR data acquired using different MRI scan acquisitions and aspects of repeatability and reliability.speed of response, resistance changes) to provide more information about vascular health. Techniques to analyse CVR data in different ways (e.g.The physiology involved in the vascular response to CO 2 and how it reflects regional and/or systemic vascular health.Methods of administering the CO 2 stimulus during MRI (stimulus pattern, apparatus).In pursuit of this aim, a better understanding of a number of aspects are needed.
This Research Topic is intended to attract manuscripts that advance the use of MRI-based CVR parameters in clinical assessments of cerebrovascular health using CO 2 as a stimulus. Because CVR varies across the healthy brain and in focal pathologies, whole-brain neuroimaging techniques such as Magnetic Resonance Imaging (MRI) are used to map CVR parameters, providing insight into a number of clinical aspects of cerebrovascular health. For example, reductions in the amplitude of CVR are associated with an enhanced risk of stroke and delays in the timing of CVR are associated with dementia. stenosis) and other factors impacting the CBF supply. It measures the regulatory ability of the cerebral vasculature, and is used to assess cerebrovascular health the ability of the brain to cope with changes in vascular anatomy (e.g. CVR is expressed as the ratio of the change in CBF and the change in the vasoactive stimulus. Simplistically, CVR can be thought of as a stress test of the brain vasculature. Cerebrovascular reactivity (CVR) measures the brain blood flow (CBF) response to a vasoactive stimulus such as carbon dioxide (CO 2).
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